Doesn't having the lens and sensor as a group, while screen and handle as another makes it more ergonomically sounded?

Your hand will still be straight and screen facing you while you do low /high angle shots.

Current set up (DSLR layout with swivel/tilting screen) means while you can see what you're shooting, you hand still has to be in an awkward position.

I understand for DSLR, but mirrorless doesn't have that limitation anymore.