Open to feedback.
As someone who has lived in three provinces and road-tripped extensively across the country, these are the distinctive cultural sub-regions that I've noticed, in my 30+ years here. I've divided Canada into 7 Primary Cultural Regions, each divided into two or more subregions:

• Newfoundland & Labrador - ????Red
• Maritimes - ????Purple
• Québec - ???? Blue
• Ontario - ????Pink
• Prairies - ????Yellow
• BC - ???? Green
• The North - ????Brown/Tan

Map is based on Census Divisions, although I've manually split up a small number of census divisions (around 6-8) for better boundary alignment.